Investigating how a brain component affects the clearance of amyloid-β in Alzheimer's disease
Heparan sulfate proteoglycan in the brain vascular clearance of amyloid-β and Alzheimer's disease
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-10892336
This study is looking at how a special molecule in the brain helps clear away a substance linked to Alzheimer's disease, and it aims to find out how problems with this process might make the disease worse, which could lead to new treatments for people with Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10892336 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of heparan sulfate, a type of molecule in the brain, in the clearance of amyloid-β, which is linked to Alzheimer's disease. The researchers will explore how disruptions in this clearance process contribute to the progression of Alzheimer's. By studying brain blood vessels and their interactions with amyloid-β, the team aims to uncover new mechanisms that could lead to effective treatments for this condition. The approach includes examining the molecular interactions and integrity of brain blood vessels in patients with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those experiencing cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to amyloid-β accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve amyloid-β clearance and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding amyloid-β clearance mechanisms, but this specific approach focusing on heparan sulfate is relatively novel.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, LIANCHUN — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: WANG, LIANCHUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease patient