Investigating how a beta blocker can improve wound healing in diabetic foot ulcers
Multiple targets for beta adrenergic antagonist mediate wound healing
This study is looking at how a medication called timolol can help heal diabetic foot ulcers, and it’s for people with diabetes who are dealing with these tough wounds; researchers want to see how well it works and understand why, while also using technology to predict which ulcers might heal with regular treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Northern California Health Care Sys NIH-funded |
| Lab location | 1 site (Mather, United States) |
| Project ID | NIH-10910976 on NIH RePORTER |
What this research studies
This research focuses on diabetic foot ulcers, a serious complication for many patients with diabetes. It explores the use of timolol, a beta adrenergic receptor antagonist, applied topically to enhance the healing process of these ulcers. The study aims to understand the mechanisms behind timolol's effectiveness by analyzing wound tissue and microbiota from patients treated with the drug compared to those who are not. Additionally, machine learning techniques will be employed to predict which ulcers are likely to heal with standard care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with diabetes who are experiencing diabetic foot ulcers.
Not a fit: Patients without diabetes or those who do not have diabetic foot ulcers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved healing of diabetic foot ulcers, reducing the risk of severe complications such as infections and amputations.
How similar studies have performed: Previous studies have shown promise in using beta blockers for wound healing, but this specific approach is novel and aims to uncover new mechanisms.
Where this research is happening
Mather, United States
- VA Northern California Health Care Sys — Mather, United States (Active)
Researchers
- Principal investigator: Isseroff, Roslyn Rivkah — VA Northern California Health Care Sys
- Study coordinator: Isseroff, Roslyn Rivkah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.