Investigating how a bacterium manipulates immune signaling for infection
Ehrlichia Notch SLiM-activated oncoprotein inhibition of apoptosis
This study is looking at how the tick-borne germ Ehrlichia chaffeensis tricks our immune system to cause illness, with the hope of finding new ways to help patients fight off these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10979151 on NIH RePORTER |
What this research studies
This research focuses on understanding how the bacterium Ehrlichia chaffeensis, which causes a serious tick-borne illness, interacts with the immune system. The study aims to uncover the molecular mechanisms by which this bacterium hijacks the Notch signaling pathway to facilitate its infection process. By examining specific protein interactions, the research seeks to identify potential targets for therapeutic intervention. Patients may benefit from insights gained into how to better combat infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with human monocytotropic ehrlichiosis or those at high risk of infection.
Not a fit: Patients with other unrelated infections or conditions not involving Ehrlichia chaffeensis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by Ehrlichia chaffeensis.
How similar studies have performed: Previous research has shown success in understanding pathogen-host interactions, but this specific approach to studying Ehrlichia chaffeensis is relatively novel.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Mcbride, Jere W — University of Texas Med Br Galveston
- Study coordinator: Mcbride, Jere W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.