Investigating how a bacterial toxin affects immune cell function in gum disease
Cytolethal distending toxin mediated modulation of phagocytic function
This study is looking at how a toxin from a specific bacteria affects the immune system in people with localized aggressive periodontitis, with the goal of finding new ways to help manage gum infections better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10917128 on NIH RePORTER |
What this research studies
This research explores the effects of cytolethal distending toxin (Cdt) produced by the bacterium A. actinomycetemcomitans on the immune response, particularly focusing on phagocytic function in patients with localized aggressive periodontitis (LAP). The study aims to understand how this toxin influences the body's defense mechanisms against bacterial infections in the gums. By examining the interactions between the toxin and immune cells, the research seeks to uncover potential new therapeutic approaches for treating periodontitis. The findings could lead to better management strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with localized aggressive periodontitis.
Not a fit: Patients without periodontal disease or those with other forms of gum disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in patients with gum disease.
How similar studies have performed: Previous research has shown that understanding bacterial toxins can lead to significant advancements in treating infectious diseases, suggesting potential success for this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kim, Taewan John — University of Pennsylvania
- Study coordinator: Kim, Taewan John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.