Investigating how 7-deazaguanines modify DNA
Official title: 7-deazaguanines in DNA: mechanism and structure of complex genome modification
Funded at Portland State University · NIH-10928709 · Data updated 2026-11-12
This study is looking at how a special type of modified building block in DNA affects its structure and function in bacteria, which could help us understand more about genetic stability and diseases that might impact patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland State University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $397,265 |
| NIH project number | 5R01GM146075-03 |
| Project ID | NIH-10928709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or those interested in the molecular basis of DNA modifications.
✕Less likely to help
Patients with conditions unrelated to DNA modification processes may not receive direct benefits from this research.
What this research studies
This research explores the mechanisms by which 7-deazaguanines, a type of modified nucleotide, affect DNA structure and function. It focuses on understanding the proteins involved in creating these modifications in bacteria and how they contribute to essential processes like DNA protection and gene regulation. By studying these complex interactions, the research aims to shed light on the broader implications of DNA modifications across different organisms. Patients may benefit from insights gained into genetic stability and disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding genetic modifications that impact health and disease.
How similar studies have gone: While the specific focus on 7-deazaguanines is novel, similar research on DNA modifications has shown promising results in understanding genetic processes.
Where this research is happening
-
Portland State University
Portland, United States Active
Researchers
- Principal investigator: Iwata-Reuyl, Dirk — Portland State University
- Study coordinator: Iwata-Reuyl, Dirk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.