Investigating how 3D structures of genomes are organized in cells
Official title: Can one size fit all? - High-Resolution 3D Genome Spatial Organization Inference with Generalizable Models
Funded at University of Colorado · NIH-10910041 · Data updated 2026-11-12
This study is exploring how the way our genes are arranged in cells affects how they work, using advanced computer models to help us understand these patterns better, which could give us new insights into health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Colorado Springs, United States) |
| Project start | August 22, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $322,244 |
| NIH project number | 5R35GM150402-02 |
| Project ID | NIH-10910041 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by chromosomal structure and organization.
✕Less likely to help
Patients with conditions unrelated to genetic or chromosomal abnormalities may not benefit from this research.
What this research studies
This research focuses on understanding the three-dimensional organization of genomes within cells using advanced computational models. By employing chromosome conformation capture techniques, particularly Hi-C, the study aims to reveal how genetic and epigenetic mechanisms influence gene expression through the spatial arrangement of chromosomes. The principal investigator will develop machine learning-based models to analyze high-resolution genome structures, addressing key questions about their organization and variability across different cells. This work could lead to new insights into the fundamental processes of biology and disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and potentially lead to new therapeutic strategies for genetic disorders.
How similar studies have gone: Previous research using chromosome conformation capture techniques has shown promise in understanding genome organization, indicating that this approach has potential for success.
Where this research is happening
-
University of Colorado
Colorado Springs, United States Active
Researchers
- Principal investigator: Oluwadare, Oluwatosin — University of Colorado
- Study coordinator: Oluwadare, Oluwatosin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.