Investigating hot flashes and blood vessel function in women
Official title: Hot Flashes and Neurovascular Function in Women
Funded at Mayo Clinic Rochester · NIH-11075859 · Data updated 2026-11-12
This study is looking at how hot flashes during menopause might impact blood vessel health in women, and it’s for women who experience different levels of hot flashes to help us understand their heart health better as they get older.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $162,630 |
| NIH project number | 5K01HL148144-05 |
| Project ID | NIH-11075859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are midlife women experiencing hot flashes, particularly those with varying frequencies of these symptoms.
✕Less likely to help
Patients who are not experiencing hot flashes or are outside the midlife age range may not receive benefit from this research.
What this research studies
This research focuses on understanding how hot flashes, a common symptom during menopause, affect blood vessel function in women. It aims to compare the microvascular and autonomic functions in women experiencing different frequencies of hot flashes. By assessing these functions, the study seeks to uncover the relationship between hot flashes and cardiovascular health, which is crucial for women's well-being as they age. The research will involve objective assessments to ensure accurate data collection and analysis.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for hot flashes and associated cardiovascular risks in menopausal women.
How similar studies have gone: Previous research has shown that understanding the relationship between menopausal symptoms and cardiovascular health can lead to significant advancements in women's health management.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Baker, Sarah Elizabeth — Mayo Clinic Rochester
- Study coordinator: Baker, Sarah Elizabeth
Related research
Other NIH-funded projects on the same topics.
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Using PhytoSERM to help manage menopausal hot flashes and support brain health.
This study is looking at how a new treatment called PhytoSERM can help relieve menopausal symptoms like hot flashes and support brain health in women going through menopause, offering a safer option than traditional hormone therapy.
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Fezolinetant to reduce hot flashes in men on androgen-deprivation therapy
This trial will test whether taking fezolinetant once daily for 4 weeks reduces how often and how severe hot flashes are in men with prostate cancer who are on androgen-deprivation therapy.
-
Plant extract supplement for menopausal symptoms in women around menopause
A plant-extract dietary supplement is being tested to see if it helps hot flashes and related symptoms in women aged 42–60 who are nearing or just past menopause, compared with a placebo.
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Shatavari-based herbal extract to help menopausal symptoms
This study tests whether an 8-week daily herbal extract containing Shatavari can reduce menopausal symptoms in postmenopausal women, compared with a placebo.
-
Can fezolinetant reduce hot flashes for Indian women going through menopause
This study tests whether fezolinetant can lessen hot flashes and night sweats in Indian menopausal women who have persistent vasomotor symptoms.
-
Wearable cooling device to ease hot flashes in men on ADT for prostate cancer
A randomized test to see if the Embr Wave wearable can reduce hot flashes in men with prostate cancer on androgen deprivation therapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.