Investigating hepatitis B DNA in patients with HIV and hepatitis B alone
Official title: HBV cccDNA and integrated DNA in HIV coinfection and HBV monoinfection
Funded at Beth Israel Deaconess Medical Center · NIH-10882266 · Data updated 2026-11-12
This study is looking at how the hepatitis B virus behaves in people with chronic hepatitis B, especially those who also have HIV, to see how it affects their treatment and find ways to predict how well they might respond to therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 3, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $847,428 |
| NIH project number | 1R56AI179574-01 |
| Project ID | NIH-10882266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with chronic hepatitis B, particularly those who may also be living with HIV.
✕Less likely to help
Patients who do not have chronic hepatitis B or HIV may not benefit from this research.
What this research studies
This research focuses on understanding the role of hepatitis B virus (HBV) DNA in patients who have chronic hepatitis B (CHB) with or without HIV coinfection. The study aims to evaluate the levels and activity of two forms of HBV DNA in the liver and blood, and how these relate to treatment responses. By analyzing liver and blood samples, researchers will explore how epigenetic factors influence HBV DNA activity and identify potential biomarkers that could predict treatment outcomes. This work seeks to improve the understanding of HBV treatment and the factors that contribute to achieving a functional cure.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for chronic hepatitis B, potentially increasing the rates of functional cure.
How similar studies have gone: Previous research has shown promise in understanding HBV dynamics, but this study aims to explore novel aspects that have not been extensively tested.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Lau, Daryl T — Beth Israel Deaconess Medical Center
- Study coordinator: Lau, Daryl T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.