Investigating heart signaling pathways in patients with polycystic kidney disease.
mTORC1/2 Signaling in the Heart in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
This study is looking at how certain signals in the heart affect heart problems in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), and it will test new treatments to see if they can help reduce heart issues for these patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10950347 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific signaling pathways in the heart, particularly mTORC1 and mTORC2, contribute to heart disease in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The study aims to explore the mechanisms behind cardiac hypertrophy, which is an enlargement of the heart muscle, and how it occurs independently of hypertension. Researchers will test new agents that inhibit these pathways to see if they can effectively reduce heart-related complications in ADPKD patients. By using advanced therapeutic approaches, including novel antisense oligonucleotides, the research seeks to provide insights into better treatment options for heart disease in this patient population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease who may be experiencing heart-related issues.
Not a fit: Patients without a diagnosis of ADPKD or those who do not have any heart complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve heart health and overall outcomes for patients with ADPKD.
How similar studies have performed: Previous research has shown promising results with mTOR inhibitors in other contexts, suggesting potential for success in this novel application.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Edelstein, Charles Louis — VA Eastern Colorado Health Care System
- Study coordinator: Edelstein, Charles Louis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.