Investigating heart problems caused by cancer treatments in dogs and humans
Credentialing a Cross-Species Platform to Investigate Cancer Therapy-Associated Cardiovascular Toxicity
This study is looking at how certain cancer treatments can affect heart health, using pet dogs with cancer to help us understand these effects better, which could ultimately help both dogs and people who are undergoing similar therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10687058 on NIH RePORTER |
What this research studies
This research focuses on understanding the cardiovascular complications that arise from cancer therapies, particularly in patients receiving new treatments like small molecule inhibitors and immunotherapeutics. By using pet dogs with spontaneous cancer as a model, the study aims to explore the mechanisms behind these toxicities in a more clinically relevant setting. The approach combines in vitro studies with animal models to provide insights into how these therapies affect heart health over time. This could lead to better monitoring and intervention strategies for both canine and human patients undergoing cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include cancer patients receiving novel therapies that may cause cardiovascular toxicity, as well as pet dogs undergoing similar treatments.
Not a fit: Patients who are not receiving cancer treatments or those whose therapies do not have cardiovascular implications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for monitoring and managing heart-related side effects in cancer patients.
How similar studies have performed: Previous research has shown success in using animal models to study drug toxicity, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Tufts Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Jaffe, Iris Z — Tufts Medical Center
- Study coordinator: Jaffe, Iris Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.