Investigating heart problems caused by cancer treatment in childhood cancer survivors
Official title: Genomics-based Mechanistic Investigation of Cancer-treatment Related Cardiotoxicity among Survivors of Childhood Cancer
Funded at St. Jude Children's Research Hospital · NIH-11083646 · Data updated 2026-11-12
This study is looking at how cancer treatments from childhood might affect heart health later on, and it's for people who survived childhood cancer to help us learn more about the connection between those treatments and heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | May 3, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $689,693 |
| NIH project number | 5R01CA290112-02 |
| Project ID | NIH-11083646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have survived childhood cancer and are experiencing cardiovascular issues or are at risk for such conditions.
✕Less likely to help
Patients who have not undergone cancer treatment during childhood or those without a history of childhood cancer are unlikely to benefit from this research.
What this research studies
This research focuses on understanding how cancer treatments received during childhood can lead to heart disease later in life. It aims to explore the genetic and health behavior factors that contribute to cardiovascular issues among survivors of childhood cancer. By examining various cardiometabolic outcomes, such as obesity and hypertension, the study seeks to identify the mechanisms linking cancer treatment to heart problems. Participants will be involved in assessments that look at their genetic makeup and health history to better understand these risks.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing heart disease in childhood cancer survivors.
How similar studies have gone: Previous research has shown that understanding the genetic factors related to treatment side effects can lead to better health outcomes, indicating potential success for this approach.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Wang, Zhaoming — St. Jude Children's Research Hospital
- Study coordinator: Wang, Zhaoming
Related research
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Genomics of childhood ALL across global populations
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Genomics of childhood ALL across diverse populations
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Targeting retrotransposons to help kids with hard-to-treat cancers like neuroblastoma
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Better identifying late health problems in adult survivors of childhood cancer
This project uses computer learning with clinic exams, medical records, genetics, and survey answers to more accurately find conditions like diabetes, high blood pressure, and heart problems in adults who survived childhood cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.