Investigating heart metabolism changes during heart enlargement
Official title: Hexosamine biosynthesis pathway metabolism during cardiac hypertrophy
Funded at Seattle Children's Hospital · NIH-10980556 · Data updated 2026-11-12
This study is looking at how certain heart diseases make the heart work too hard and grow bigger, and it aims to find out how this affects the heart's energy use, which could help discover new ways to keep hearts healthier and prevent heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 20, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $735,425 |
| NIH project number | 5R01HL163103-03 |
| Project ID | NIH-10980556 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with conditions that cause pressure overload on the heart, such as aortic stenosis or hypertension.
✕Less likely to help
Patients with heart conditions unrelated to pressure overload or those with advanced heart failure may not benefit from this research.
What this research studies
This research focuses on how various heart diseases, such as aortic stenosis and coarctation, lead to pressure overload on the heart, causing it to enlarge (hypertrophy). The study aims to understand the metabolic changes that occur in the heart during this process, particularly how the heart shifts its energy sources from fatty acids to glucose. By exploring the mechanisms behind these changes, the research seeks to identify new therapeutic strategies that could help the heart adapt better and prevent heart failure. The research involves both animal models and human samples to uncover the underlying biochemical pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and prevent heart failure in patients with pressure overload conditions.
How similar studies have gone: Previous research has shown promising results in understanding metabolic changes in the heart, but this specific approach to targeting the hexosamine biosynthesis pathway is relatively novel.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Olson, Aaron K — Seattle Children's Hospital
- Study coordinator: Olson, Aaron K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.