Investigating heart issues related to Dravet syndrome.
Defining Novel Mechanisms of Sudden Death in Dravet Syndrome: Dysregulation of Sodium Channels in the Heart
This study is looking at how Dravet syndrome, a serious type of epilepsy, might cause heart problems that can lead to sudden death, and it aims to find ways to protect the heart by understanding the connection between the brain and heart in people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10983776 on NIH RePORTER |
What this research studies
This research focuses on understanding how Dravet syndrome, a severe form of epilepsy, may lead to sudden cardiac death due to disruptions in sodium channels in the heart. By using specific models of Dravet syndrome, the researchers aim to explore the connection between brain and heart functions, particularly how defects in sodium channels can cause dangerous heart rhythms. The study will involve examining the structural and functional changes in heart cells and testing potential treatments to prevent these life-threatening conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Dravet syndrome who are at risk for sudden cardiac events.
Not a fit: Patients without Dravet syndrome or those who do not have a history of cardiac issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing sudden cardiac death in patients with Dravet syndrome.
How similar studies have performed: Previous research has indicated potential links between epilepsy and cardiac arrhythmias, suggesting that this approach may yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Radwanski, Przemyslaw — Ohio State University
- Study coordinator: Radwanski, Przemyslaw
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.