Investigating heart injury caused by low oxygen levels after a heart attack
Official title: Microphysiological Systems to Study Hypoxic Cardiac Injury
Funded at University of Arkansas at Fayetteville · NIH-11223632 · Data updated 2026-11-12
This study is looking at how low oxygen levels impact heart tissue after a heart attack, using special systems to mimic those conditions, so we can learn more about how to help patients recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | January 2, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL157722-03 |
| Project ID | NIH-11223632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an acute myocardial infarction or are at high risk for heart attacks.
✕Less likely to help
Patients with chronic heart conditions unrelated to acute myocardial infarction may not benefit from this research.
What this research studies
This research focuses on understanding how low oxygen levels affect heart tissue after an acute myocardial infarction, commonly known as a heart attack. By creating advanced microphysiological systems that can precisely control oxygen levels, the researchers aim to mimic the conditions of heart tissue during and after a heart attack. This approach will help identify the molecular pathways involved in heart injury and how heart cells respond to these low oxygen conditions. Patients may benefit from insights gained that could lead to improved treatments for heart attack recovery.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better protect heart tissue during and after a heart attack.
How similar studies have gone: Previous research using microphysiological systems has shown promise in understanding cardiac responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Rexius, Megan L. — University of Arkansas at Fayetteville
- Study coordinator: Rexius, Megan L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.