Investigating heart health and exercise in people with HIV
Official title: Low Cardiorespiratory Fitness and Chronotropic Incompetence inHIV: Risk Factors, Cardiovascular Implications, and Exercise Training as Treatment
Funded at University of California, San Francisco · NIH-11045688 · Data updated 2026-11-12
This study is looking at how being less fit and having trouble increasing your heart rate can impact heart health for people living with HIV, and it will explore how exercise might help improve heart function and overall fitness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $197,748 |
| NIH project number | 5K23HL172699-02 |
| Project ID | NIH-11045688 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may be experiencing low cardiorespiratory fitness or related cardiovascular issues.
✕Less likely to help
Patients who do not have HIV or those with advanced cardiovascular disease may not benefit from this research.
What this research studies
This research focuses on understanding how low cardiorespiratory fitness and chronotropic incompetence affect heart health in individuals living with HIV. The study aims to analyze the cardiovascular implications of these conditions and explore how exercise training can serve as a treatment option. Patients will be involved in hands-on research that combines clinical trials and advanced cardiac imaging to assess their fitness levels and heart function. The goal is to develop effective strategies to improve cardiovascular health among this population.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health and exercise recommendations for patients with HIV.
How similar studies have gone: Previous research has shown promising results in improving cardiovascular health through exercise interventions in similar populations, indicating that this approach has potential.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Durstenfeld, Matthew — University of California, San Francisco
- Study coordinator: Durstenfeld, Matthew
Related research
Other NIH-funded projects on the same topics.
-
IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
-
ALS risk factors in a long-term ALS study
A long-term ALS study is looking at which factors may influence disease risk and progression in people living with ALS.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data
Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.
-
P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.