Investigating heart function and metabolism in patients with heart failure and preserved ejection fraction.
Official title: Analysis of Single Cell Transcriptomics and Cardiac Metabolism in Heart Failure with Preserved Ejection Fraction
Funded at Johns Hopkins University · NIH-10999450 · Data updated 2026-11-12
This study is looking at how obesity impacts heart function in people with heart failure that still pumps well, hoping to find new ways to help patients feel better by examining heart tissue samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $197,964 |
| NIH project number | 5K23HL166770-03 |
| Project ID | NIH-10999450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction, particularly those who are obese.
✕Less likely to help
Patients with heart failure and reduced ejection fraction or those without obesity may not benefit from this research.
What this research studies
This research focuses on understanding heart failure with preserved ejection fraction (HFpEF), particularly how obesity affects heart function and metabolism. By analyzing human heart tissue samples using advanced techniques like single nuclei RNA sequencing and multi-omic analysis, the study aims to identify distinct cellular and metabolic profiles in HFpEF patients. This could lead to better-targeted therapies and improve patient outcomes. The research will also explore how the heart's metabolism changes in these patients, providing insights into their unique clinical characteristics.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from heart failure with preserved ejection fraction.
How similar studies have gone: Previous research has shown promise in using similar bioinformatics approaches to analyze heart failure, indicating potential for success in this novel investigation.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Hahn, Virginia Shalkey — Johns Hopkins University
- Study coordinator: Hahn, Virginia Shalkey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.