Investigating heart function and energy metabolism in people living with HIV
Official title: Cardiac Energy Metabolism and Diastolic Dysfunction in PLWH
Funded at Johns Hopkins University · NIH-10819127 · Data updated 2026-11-12
This study is looking at how heart health is affected in people with HIV who are taking medication, focusing on how the heart's energy production might relate to heart function problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $534,397 |
| NIH project number | 5R01HL164143-02 |
| Project ID | NIH-10819127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and experiencing heart-related symptoms.
✕Less likely to help
Patients who are not living with HIV or those without any cardiac symptoms may not benefit from this research.
What this research studies
This research focuses on understanding how heart function is affected in people living with HIV who are on antiretroviral therapy. It aims to explore the relationship between cardiac energy metabolism and left ventricular diastolic dysfunction, a condition that can lead to serious heart issues. By using advanced imaging techniques, the study will assess how energy production in heart cells is impacted and how this relates to heart health in individuals with HIV. The goal is to identify underlying mechanisms that contribute to heart problems in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for heart dysfunction in people living with HIV.
How similar studies have gone: Previous research has indicated that cardiac energy metabolism plays a significant role in heart health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Weiss, Robert G — Johns Hopkins University
- Study coordinator: Weiss, Robert G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.