Investigating heart changes in childhood cancer survivors treated with anthracyclines
Official title: The Clinical Relevance of Anthracycline-Related Cardiac Remodeling in Childhood Cancer Survivors
Funded at University of California, San Diego · NIH-10901989 · Data updated 2026-11-12
This study is looking at how a common cancer treatment for kids might change the shape of the heart in childhood cancer survivors, with the goal of finding ways to keep their hearts healthy as they grow up.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $196,591 |
| NIH project number | 5K23HL163456-02 |
| Project ID | NIH-10901989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are childhood cancer survivors who have received anthracycline treatment and are experiencing or at risk for cardiac issues.
✕Less likely to help
Patients who have not received anthracycline treatment or those without a history of childhood cancer may not benefit from this research.
What this research studies
This research focuses on understanding how anthracycline chemotherapy, commonly used in pediatric cancer treatment, affects the heart's structure in childhood cancer survivors. The study aims to identify specific changes in the shape of the heart's left ventricle that may lead to heart dysfunction over time. By examining the relationship between these changes and factors like physical activity, the research seeks to develop targeted early treatment strategies to improve heart health in these survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health management strategies for childhood cancer survivors, potentially reducing the risk of heart failure.
How similar studies have gone: Previous research has shown that early intervention in cardiac health can improve outcomes for patients with similar conditions, suggesting that this approach may be promising.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Narayan, Hari Kope — University of California, San Diego
- Study coordinator: Narayan, Hari Kope
Related research
Other NIH-funded projects on the same topics.
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Strategies to Find and Reconnect Adolescent and Young Adult Cancer Survivors to Adult Follow-Up Care
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-
Using ECG and AI to find childhood cancer survivors at risk for late cardiomyopathy
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STRENGTH: Time-restricted eating to reduce cardiometabolic risk in childhood cancer survivors
A program tests whether time-restricted eating can lower heart and diabetes risks for adults who survived childhood cancer.
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Family-centered communication help for young adult survivors of childhood cancer
A K08 grant to develop and pilot a tailored family-centered communication program to help young adult survivors of childhood cancer manage their ongoing care.
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Digital self-management and peer mentoring to help childhood cancer survivors transition to adult care
A digital, mentor-supported program helps young survivors manage their health as they move from pediatric to adult follow-up care.
-
How Medicaid affects care for adults who survived childhood cancer
This project looks at how Medicaid shapes healthcare experiences for adults who had cancer as children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.