Investigating heart and blood vessel issues in South African youth with HIV
Understanding Inflammatory and Metabolic Pathways of Myocardial and Vascular Dysfunction in South African Youth Living with Perinatal HIV
This study is looking at how HIV affects the hearts and blood vessels of young people who were born with the virus, to find early signs of heart problems before they show up later in life, and it’s comparing them to other young people with HIV and those without HIV to better understand the risks involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10833024 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV affects the heart and blood vessels in young people who were born with the virus. It aims to identify early signs of cardiovascular disease in these youth, who may not show symptoms until later in life. By comparing them with other youth who are either HIV-positive but not perinatally infected or uninfected, the study seeks to uncover the underlying metabolic and inflammatory processes that contribute to heart problems. Advanced imaging techniques will be used to assess heart function and blood vessel health, providing crucial insights into potential risks for heart failure and other cardiovascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are young individuals aged 0-21 years who were born with HIV and are currently living in sub-Saharan Africa.
Not a fit: Patients who are older than 21 or those who do not have perinatally acquired HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of cardiovascular diseases in youth living with perinatal HIV.
How similar studies have performed: Previous studies have indicated significant cardiovascular issues in adults with HIV, suggesting that this research could build on established findings, although the specific focus on youth with perinatal HIV is relatively novel.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Jao, Jennifer — Lurie Children's Hospital of Chicago
- Study coordinator: Jao, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.