Investigating hearing loss in mouse models of Alzheimer's disease
Official title: Behavioral and physiological measurements of hearing in mouse models of Alzheimer's Disease
Funded at State University of New York at Buffalo · NIH-10815792 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease might affect hearing by using mice to see how changes in the brain impact their ability to hear, which could help us understand similar issues in people with Alzheimer's.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $162,313 |
| NIH project number | 5R03AG081747-02 |
| Project ID | NIH-10815792 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or related dementias who also experience hearing loss.
✕Less likely to help
Patients without Alzheimer's disease or significant hearing loss may not benefit from this research.
What this research studies
This research explores the relationship between Alzheimer's disease and hearing loss using mouse models. It aims to understand how specific brain pathologies associated with Alzheimer's affect hearing by employing behavioral and physiological assessments. The study will utilize various techniques to measure hearing in awake mice, providing insights that could be more reflective of human experiences. By comparing results across different mouse strains and genders, the research seeks to clarify the inconsistencies found in previous studies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of hearing loss in patients with Alzheimer's disease.
How similar studies have gone: While there has been some research on hearing loss in Alzheimer's patients, this approach using mouse models is relatively novel and aims to fill gaps in existing knowledge.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Dent, Micheal L — State University of New York at Buffalo
- Study coordinator: Dent, Micheal L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.