Investigating harmful interactions between psychoactive drugs
Drug interactions involving psychoactive drugs
This study is looking at how different mental health medications can interact with each other in older adults, to help make sure they stay safe and healthy while taking their prescriptions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10992160 on NIH RePORTER |
What this research studies
This research focuses on the interactions between psychoactive drugs, particularly in older adults who often take multiple medications for mental health disorders. It aims to identify harmful drug interactions that can lead to serious side effects, hospitalizations, or even death. By analyzing clinical endpoints rather than just drug concentration changes, the study seeks to provide a clearer understanding of how these interactions affect patient health. The research will also explore the associations between psychoactive drugs and conditions like venous thromboembolism and serious bleeding.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and over, who are prescribed psychoactive medications.
Not a fit: Patients who are not taking psychoactive medications or are younger than 65 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer prescribing practices and improved health outcomes for patients taking psychoactive medications.
How similar studies have performed: While there have been studies on drug interactions, this research aims to fill a gap by systematically examining clinical endpoints related to psychoactive drug interactions, making it a novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Leonard, Charles Edward — University of Pennsylvania
- Study coordinator: Leonard, Charles Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.