Investigating gut bacteria's role in predicting cognitive decline in older adults
miRNAs in the gut-brain axis to predict the risk of cognitive decline in older adults
['FUNDING_R21'] · UNIVERSITY OF SOUTH FLORIDA · NIH-10826804
This study is looking at how the bacteria in your gut might affect memory and thinking as we age, especially for those at risk of Alzheimer's, and it hopes to find clues that could help prevent cognitive decline in older adults.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10826804 on ClinicalTrials.gov |
What this research studies
This research explores how changes in gut bacteria and their metabolites may influence cognitive decline and the progression of Alzheimer's disease in older adults. By examining the relationship between gut microbiome signatures and cognitive health, the study aims to identify specific microRNAs produced in the gut that could serve as biomarkers for predicting the risk of cognitive decline. Participants will be involved in assessments that analyze their gut health and cognitive function over time, contributing to a better understanding of the gut-brain connection. The ultimate goal is to uncover mechanisms that could lead to new prevention strategies for age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those experiencing mild cognitive impairment or at risk for Alzheimer's disease.
Not a fit: Patients under 65 years of age or those with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of individuals at risk for cognitive decline, allowing for timely interventions.
How similar studies have performed: Previous research has shown promising results in understanding the gut-brain axis, suggesting that this approach could yield significant insights into cognitive decline.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YADAV, HARIOM — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: YADAV, HARIOM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.