Investigating gut bacteria's role in predicting cognitive decline in older adults
Official title: miRNAs in the gut-brain axis to predict the risk of cognitive decline in older adults
Funded at University of South Florida · NIH-10826804 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect memory and thinking as we age, especially for those at risk of Alzheimer's, and it hopes to find clues that could help prevent cognitive decline in older adults.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $424,952 |
| NIH project number | 1R21AG085881-01 |
| Project ID | NIH-10826804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above, particularly those experiencing mild cognitive impairment or at risk for Alzheimer's disease.
✕Less likely to help
Patients under 65 years of age or those with advanced Alzheimer's disease may not benefit from this research.
What this research studies
This research explores how changes in gut bacteria and their metabolites may influence cognitive decline and the progression of Alzheimer's disease in older adults. By examining the relationship between gut microbiome signatures and cognitive health, the study aims to identify specific microRNAs produced in the gut that could serve as biomarkers for predicting the risk of cognitive decline. Participants will be involved in assessments that analyze their gut health and cognitive function over time, contributing to a better understanding of the gut-brain connection. The ultimate goal is to uncover mechanisms that could lead to new prevention strategies for age-related cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to early identification of individuals at risk for cognitive decline, allowing for timely interventions.
How similar studies have gone: Previous research has shown promising results in understanding the gut-brain axis, suggesting that this approach could yield significant insights into cognitive decline.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Yadav, Hariom — University of South Florida
- Study coordinator: Yadav, Hariom
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.