Investigating glycogen metabolism in Ewing's Sarcoma for better diagnosis and treatment
Official title: Targeting Glycogen Metabolism in Ewing's Sarcoma: Diagnostic, Prognostic, and Therapeutic Applications
Funded at University of Florida · NIH-11061059 · Data updated 2026-11-12
This study is looking at how a type of sugar stored in the body, called glycogen, affects the growth of Ewing's Sarcoma, a bone cancer that mostly affects kids, to find new ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $531,270 |
| NIH project number | 5R01CA288696-02 |
| Project ID | NIH-11061059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with Ewing's Sarcoma.
✕Less likely to help
Patients with other types of cancers or those who do not have Ewing's Sarcoma may not benefit from this research.
What this research studies
This research focuses on Ewing's Sarcoma, a common pediatric bone cancer, by exploring the role of glycogen metabolism in its progression. The team aims to understand how glycogen accumulation, a hallmark of this cancer, can be targeted for new diagnostic and therapeutic strategies. Using advanced techniques like MALDI imaging, they will analyze tumor specimens to identify the relationship between glycogen levels and tumor growth. The research includes testing various methods to inhibit glycogen synthesis and assess their effectiveness in reducing tumor size in animal models.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve outcomes for patients with Ewing's Sarcoma.
How similar studies have gone: Previous research has shown promising results in targeting cancer metabolism, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Sun, Ramon C. — University of Florida
- Study coordinator: Sun, Ramon C.
Related research
Other NIH-funded projects on the same topics.
-
Testing new therapies for pediatric and young adult sarcoma, kidney, and liver cancers
Researchers are testing new drugs and smart combinations in models of pediatric cancers to help guide future treatments for kids and young adults.
-
Precision 3D Imaging to Monitor Kaposi Sarcoma (KS) with SkinScan3D
A new portable 3D imaging tool called SkinScan3D will help doctors measure KS skin lesions more accurately and quickly, especially in people living with HIV.
-
Precision 3D Imaging to Track Kaposi Sarcoma (KS) with SkinScan3D
A new 3D imaging tool called SkinScan3D helps doctors monitor Kaposi sarcoma lesions more accurately and quickly, especially in settings with high KS burden like East Africa and in U.S. clinics with HIV patients.
-
Rapid, bedside KS diagnosis in Africa with KS-COMPLETE
A fast, point-of-care test using skin biopsies to diagnose Kaposi’s sarcoma in sub-Saharan Africa, helping patients get results in about an hour.
-
Kaposi Sarcoma care and research in Africa during ART era
A collaborative program to better understand and improve diagnosis, treatment, and prevention of Kaposi sarcoma for people living with HIV in Zambia and Tanzania.
-
Kaposi Sarcoma in Africa: ART Era Research Network
A collaborative program in Africa and the United States will study Kaposi sarcoma in people living with HIV on ART to improve diagnosis, treatment, and prevention.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.