Investigating glycogen metabolism in Ewing's Sarcoma for better diagnosis and treatment
Targeting Glycogen Metabolism in Ewing's Sarcoma: Diagnostic, Prognostic, and Therapeutic Applications
This study is looking at how a type of sugar stored in the body, called glycogen, affects the growth of Ewing's Sarcoma, a bone cancer that mostly affects kids, to find new ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11061059 on NIH RePORTER |
What this research studies
This research focuses on Ewing's Sarcoma, a common pediatric bone cancer, by exploring the role of glycogen metabolism in its progression. The team aims to understand how glycogen accumulation, a hallmark of this cancer, can be targeted for new diagnostic and therapeutic strategies. Using advanced techniques like MALDI imaging, they will analyze tumor specimens to identify the relationship between glycogen levels and tumor growth. The research includes testing various methods to inhibit glycogen synthesis and assess their effectiveness in reducing tumor size in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with Ewing's Sarcoma.
Not a fit: Patients with other types of cancers or those who do not have Ewing's Sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve outcomes for patients with Ewing's Sarcoma.
How similar studies have performed: Previous research has shown promising results in targeting cancer metabolism, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Sun, Ramon C. — University of Florida
- Study coordinator: Sun, Ramon C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.