Investigating glucose transporters in cancer metastasis
Exploring SGLTs as Theranostic Targets for Cancer Metastasis
['FUNDING_R21'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10992131
This study is looking at how a new compound can help deliver cancer treatments more directly to tumors by using special transporters in the body, which could lead to better care and fewer side effects for people with metastatic cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10992131 on ClinicalTrials.gov |
What this research studies
This research explores the role of sodium-dependent glucose transporters (SGLTs) in various cancers, particularly their potential as targets for both diagnosis and treatment. By developing a new compound, 6FIGA, which is selectively transported by SGLTs, the study aims to improve the delivery of therapeutic radionuclides directly to cancer cells while minimizing side effects. The research utilizes advanced imaging techniques, such as PET scans, to visualize SGLT activity in tumors, which could lead to better treatment planning and outcomes for patients with metastatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic cancers, such as breast, prostate, lung, or brain cancer.
Not a fit: Patients with early-stage cancers or those not expressing SGLTs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for patients with metastatic cancer.
How similar studies have performed: While the use of glucose transporters in cancer treatment is an emerging field, this specific approach targeting SGLTs with a novel compound is relatively novel and has not been extensively tested.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUZIC, RAYMOND F — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: MUZIC, RAYMOND F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.