Investigating glucose transporters in cancer metastasis
Official title: Exploring SGLTs as Theranostic Targets for Cancer Metastasis
Funded at Case Western Reserve University · NIH-10992131 · Data updated 2026-11-12
This study is looking at how a new compound can help deliver cancer treatments more directly to tumors by using special transporters in the body, which could lead to better care and fewer side effects for people with metastatic cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $198,366 |
| NIH project number | 5R21CA280151-02 |
| Project ID | NIH-10992131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic cancers, such as breast, prostate, lung, or brain cancer.
✕Less likely to help
Patients with early-stage cancers or those not expressing SGLTs may not benefit from this research.
What this research studies
This research explores the role of sodium-dependent glucose transporters (SGLTs) in various cancers, particularly their potential as targets for both diagnosis and treatment. By developing a new compound, 6FIGA, which is selectively transported by SGLTs, the study aims to improve the delivery of therapeutic radionuclides directly to cancer cells while minimizing side effects. The research utilizes advanced imaging techniques, such as PET scans, to visualize SGLT activity in tumors, which could lead to better treatment planning and outcomes for patients with metastatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for patients with metastatic cancer.
How similar studies have gone: While the use of glucose transporters in cancer treatment is an emerging field, this specific approach targeting SGLTs with a novel compound is relatively novel and has not been extensively tested.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Muzic, Raymond F — Case Western Reserve University
- Study coordinator: Muzic, Raymond F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.