Investigating glioblastoma using advanced animal models and imaging techniques
Core C: Experimental Models
This study is exploring different ways to grow and study glioblastoma, a tough type of brain tumor, using special lab techniques and models that mimic how the tumor behaves in real life, all to help find better treatments for patients like you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10881807 on NIH RePORTER |
What this research studies
This research focuses on developing and utilizing various animal models of glioblastoma, including patient-derived xenografts and genetically engineered mice, to better understand this aggressive brain tumor. The project involves creating organoids and employing advanced imaging techniques, such as two-photon microscopy, to visualize tumor behavior in real-time. Additionally, the research aims to validate findings from these models using human biospecimens, which will help in understanding the differences in tumor characteristics across genders. By coordinating the distribution of these models, the research supports multiple experimental studies aimed at improving glioblastoma treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who may benefit from novel therapeutic strategies derived from the findings.
Not a fit: Patients with non-glioblastoma brain tumors or those who are not eligible for experimental treatments may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma patients by providing insights into tumor behavior and response to therapies.
How similar studies have performed: Other research has shown success using similar animal model approaches to study glioblastoma, indicating a promising avenue for further exploration.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Berens, Michael E. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Berens, Michael E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.