Investigating genetic variations linked to cleft lip in African and Asian populations
Official title: Structural Variation analysis of Orofacial Cleft associated genomic regions in African and Asian populations
Funded at University of Connecticut Storrs · NIH-10842402 · Data updated 2026-11-12
This study is looking at the genes that might cause orofacial clefts, which are common birth defects, especially in children from African and Asian backgrounds, to help us better understand why they happen and improve care for affected families.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $155,500 |
| NIH project number | 5R03DE033083-02 |
| Project ID | NIH-10842402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 11 years old with orofacial clefts, particularly those of African or Asian ancestry.
✕Less likely to help
Patients who do not have orofacial clefts or are outside the specified age and ancestry groups may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to orofacial clefts, a common birth defect, particularly in children of African and Asian descent. By analyzing genomic data from families affected by these conditions, the study aims to identify structural variations in genes that may play a role in the development of cleft lip. The research utilizes advanced genomic techniques to explore not only known gene regions but also intergenic areas that could influence gene expression. This comprehensive approach seeks to enhance our understanding of the etiology of orofacial clefts and improve data sharing within the pediatric research community.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential prevention strategies for orofacial clefts in affected populations.
How similar studies have gone: Previous research has successfully identified genetic factors associated with orofacial clefts, but this study's focus on structural variations represents a novel approach.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Shin, Dong-Guk — University of Connecticut Storrs
- Study coordinator: Shin, Dong-Guk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.