Investigating genetic variations linked to Alzheimer's disease
Official title: A comprehensive study of tandem repeat variation as a cause of Alzheimer's disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-10585034 · Data updated 2026-11-12
This study is looking at how certain changes in our DNA might be linked to Alzheimer's disease and dementia, and it's for anyone interested in understanding the genetic risks behind these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,206,266 |
| NIH project number | 1RF1AG075051-01A1 |
| Project ID | NIH-10585034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, as well as healthy individuals for comparison.
✕Less likely to help
Patients with non-genetic forms of dementia or those without a family history of Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how variations in tandem repeat sequences in DNA may contribute to Alzheimer's disease and certain types of dementia. By analyzing genetic data from approximately 62,000 individuals with Alzheimer's and 48,000 control subjects, the study aims to identify novel genetic markers that could indicate risk for these conditions. The research employs advanced bioinformatics techniques to systematically screen for these genetic variations, which have not been thoroughly explored in Alzheimer's cohorts before. This could lead to a better understanding of the genetic factors involved in Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new genetic markers for Alzheimer's disease, improving early diagnosis and potential treatment strategies.
How similar studies have gone: Previous research has shown success in identifying genetic markers for other neurodegenerative diseases using similar genomic approaches, suggesting potential for breakthroughs in Alzheimer's research as well.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Sharp, Andrew James — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sharp, Andrew James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.