Investigating genetic variations in repetitive DNA sequences that affect complex traits
Systematic characterization of tandem repeat variants contributing to complex traits
This study is looking at how certain tiny changes in our DNA can affect different traits and health conditions, and it’s for anyone interested in understanding how genetics might play a role in their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10982270 on NIH RePORTER |
What this research studies
This research explores how specific genetic variations in repetitive regions of DNA, known as tandem repeats, influence complex traits in humans. By utilizing advanced genomic techniques and large datasets, the study aims to identify the causal variants and biological mechanisms behind these traits. The focus is on two types of tandem repeats: short tandem repeats (STRs) and variable number tandem repeats (VNTRs), which are known to contribute significantly to genetic diversity. Patients may benefit from insights gained about how these genetic factors affect health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with complex traits or conditions that may have a genetic component.
Not a fit: Patients with conditions that are not influenced by genetic factors or those with purely environmental causes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors influencing complex traits, potentially improving personalized medicine approaches.
How similar studies have performed: Other research has shown promising results in understanding the role of genetic variations in complex traits, making this approach both relevant and potentially impactful.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Gymrek, Melissa — University of California, San Diego
- Study coordinator: Gymrek, Melissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.