Investigating genetic variations in mice to understand Alzheimer's disease
Center for Mouse Genomic Variation at Single Cell Resolution
This study is looking at how certain genetic differences in mice might affect the way genes work in relation to Alzheimer's disease, using special techniques to see these changes at a very detailed level, which could help us understand more about the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11105786 on NIH RePORTER |
What this research studies
This research focuses on identifying genetic variants that influence gene expression related to Alzheimer's disease by using advanced single-cell genomic techniques in mice. The study will analyze 38 diverse mouse strains to explore how these variants affect gene function and chromatin accessibility in various tissues. By employing both short-read and long-read sequencing methods, the research aims to uncover the complex interactions of genetic variants at a single-cell level, which could provide insights into the mechanisms underlying Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with Alzheimer's disease who are over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors contributing to Alzheimer's disease, potentially informing new treatment strategies.
How similar studies have performed: Previous research using single-cell genomics in mouse models has shown promise in understanding genetic contributions to complex diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Mortazavi, Seyed Ali — University of California-Irvine
- Study coordinator: Mortazavi, Seyed Ali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.