Investigating genetic variants linked to substance use disorders
Official title: High-Throughput Functional Genomics of Variants in Genes Linked to Substance Use Disorders
Funded at Washington University · NIH-10895531 · Data updated 2026-11-12
This study is looking at how our genes might affect substance use disorders, and it's for anyone interested in understanding how genetics can help create better treatments for addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $466,500 |
| NIH project number | 5DP1DA058706-02 |
| Project ID | NIH-10895531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of substance use disorders or those who are genetically predisposed to such conditions.
✕Less likely to help
Patients who do not have a genetic predisposition to substance use disorders may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to substance use disorders by examining thousands of genetic variants identified through previous studies. It employs advanced techniques like Massively Parallel Reporter Assays (MPRAs) to experimentally test these variants and determine their functional significance. By uncovering how these genetic variants influence behavior and addiction, the research aims to pave the way for developing targeted therapies. Patients may benefit from insights that could lead to more effective treatments tailored to their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to the development of personalized treatments for substance use disorders based on individual genetic profiles.
How similar studies have gone: Previous research has shown success in using high-throughput genomics to identify genetic factors in various disorders, suggesting a promising approach for this study.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Baldridge, Dustin M — Washington University
- Study coordinator: Baldridge, Dustin M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.