Investigating genetic variants linked to inflammatory bowel diseases
Official title: High throughput functional studies of IBD-associated GWAS variants
Funded at Univ of North Carolina Chapel Hill · NIH-11010791 · Data updated 2026-11-12
This study is looking at how our genes might play a role in inflammatory bowel diseases like Crohn's and ulcerative colitis, so that we can better understand these conditions and find new ways to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $655,744 |
| NIH project number | 5R01DK136262-03 |
| Project ID | NIH-11010791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients with other gastrointestinal disorders unrelated to inflammatory bowel diseases may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. By analyzing genomic data from patients, the study aims to identify specific genetic variants that affect gene regulation and contribute to the disease's progression. The researchers will use advanced techniques to assess how these variants influence gene activity in relevant tissues, which could lead to better insights into disease mechanisms. Patients may benefit from a deeper understanding of their condition and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with inflammatory bowel diseases.
How similar studies have gone: Previous research has shown promise in identifying genetic variants associated with other diseases, suggesting that this approach could yield valuable insights for IBD as well.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Sheikh, Shehzad Z. — Univ of North Carolina Chapel Hill
- Study coordinator: Sheikh, Shehzad Z.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.