Investigating genetic variants linked to Alzheimer's disease
Systematic analysis of functional 3’ UTR genetic variants and their relevance to Alzheimer’s Disease
This study is looking at specific genetic changes that might play a role in the development of Alzheimer's disease, helping us understand how these changes affect the way genes work, which could lead to new insights about the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10990547 on NIH RePORTER |
What this research studies
This research focuses on identifying and understanding genetic variants in the 3' untranslated regions (UTRs) of genes that may influence the development of Alzheimer's disease. By analyzing how these variants affect the regulation of mRNA abundance, the study aims to uncover the mechanisms that contribute to the disease's progression. The approach involves cataloging genetic variants and assessing their functional impact on gene expression, particularly through interactions with RNA-binding proteins and microRNAs. This could lead to a better understanding of Alzheimer's disease at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
Not a fit: Patients with Alzheimer's disease caused by non-genetic factors or those without a genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors contributing to Alzheimer's disease, potentially informing future treatments or preventive strategies.
How similar studies have performed: Previous research has shown promise in identifying genetic variants associated with Alzheimer's disease, but the specific focus on 3' UTR variants is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Xiao, Xinshu Grace — University of California Los Angeles
- Study coordinator: Xiao, Xinshu Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.