Investigating genetic variants in skin diseases
Official title: Regulatory Variants in HUMAN SKIN DISEASES
Funded at Stanford University · NIH-10806962 · Data updated 2026-11-12
This study is looking at how certain genetic changes might play a role in skin conditions like atopic dermatitis and psoriasis, and it aims to help us understand these diseases better so we can find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $447,131 |
| NIH project number | 5R01AR076965-05 |
| Project ID | NIH-10806962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atopic dermatitis or psoriasis.
✕Less likely to help
Patients with skin diseases not related to atopic dermatitis or psoriasis may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variants affect the development of inflammatory skin diseases like atopic dermatitis and psoriasis. By mapping regulatory DNA in human skin, the study aims to identify single nucleotide polymorphisms (eSNPs) that are linked to these conditions. The researchers will create human skin models to observe how these genetic changes influence gene expression and skin function. This approach could lead to better insights into the mechanisms behind these diseases and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory skin diseases.
How similar studies have gone: Previous research has shown success in using genetic mapping to understand skin diseases, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Khavari, Paul — Stanford University
- Study coordinator: Khavari, Paul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.