Investigating genetic mutations linked to blood cancer risk in healthy Nigerians
Prevalence and temporal dynamics of clonal mutations associated with the risk of hematological cancer in a cohort of clinically healthy Nigerians
This study is looking at the presence of certain genetic changes in healthy Nigerians aged 40 and older to see if they might be at risk for blood cancers or heart diseases, with the goal of helping to improve prevention strategies for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nigerian Institute of Medical Research NIH-funded |
| Lab location | 1 site (Lagos, Nigeria) |
| Project ID | NIH-11093324 on NIH RePORTER |
What this research studies
This research focuses on understanding the prevalence of specific genetic mutations known as Clonal Hematopoiesis of Indeterminate Potential (CHIP) in a group of clinically healthy Nigerians aged 40 and above. By collecting blood samples and analyzing them for mutations associated with blood cancers, the study aims to create a comprehensive database of these mutations in African populations. This could help identify individuals at risk for developing hematological malignancies and cardiovascular diseases, ultimately leading to better prevention strategies. The research employs advanced genetic sequencing techniques to ensure accurate identification of these mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are clinically healthy Nigerians aged 40 years and older.
Not a fit: Patients who are not of African descent or those with existing hematological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and prevention strategies for blood cancers in individuals of African descent.
How similar studies have performed: While there has been significant research on CHIP in other populations, this study is novel as it focuses specifically on individuals of African descent, who are underrepresented in existing studies.
Where this research is happening
Lagos, Nigeria
- Nigerian Institute of Medical Research — Lagos, Nigeria (Active)
Researchers
- Principal investigator: Oyebola, Kolapo — Nigerian Institute of Medical Research
- Study coordinator: Oyebola, Kolapo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.