Investigating genetic factors that influence the progression of Lewy body diseases and Alzheimer's disease.
Official title: Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of Synucleinopathy
Funded at University of Pennsylvania · NIH-10935312 · Data updated 2026-11-12
This study is looking at how certain genes might influence the progression of Lewy body diseases and their connection to Alzheimer's, with the goal of finding new ways to help manage these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $588,211 |
| NIH project number | 1P01AG084497-01A1 |
| Project ID | NIH-10935312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Lewy body diseases or Alzheimer's disease, particularly those with a family history of these conditions.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to Lewy body pathology may not benefit from this research.
What this research studies
This research focuses on understanding how genetic modifiers affect the progression of Lewy body diseases (LBDs) and their relationship with Alzheimer's disease. By examining the role of specific genes associated with these conditions, the study aims to uncover how these genetic factors influence the development and severity of symptoms. The research will utilize in vivo models to dissect the interactions between genetic risk factors and the pathological changes that occur at different stages of the diseases. This approach may help identify potential targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Lewy body diseases and Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Luk, Kelvin C — University of Pennsylvania
- Study coordinator: Luk, Kelvin C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.