Investigating genetic factors that influence stroke vulnerability in specific mouse strains
Genetics of stroke vulnerability in C57BL/6 mouse substrains
This study is looking at how different genetic traits in certain types of mice can affect their risk and response to stroke, with the hope that what we learn can help improve stroke treatments for people in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10862741 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic differences among various substrains of the C57BL/6 mouse affect their vulnerability to stroke. By examining these differences, researchers aim to identify specific gene variants that contribute to the severity of stroke. The study utilizes advanced sequencing techniques to gather comprehensive genetic data, which will help in mapping the genetic factors associated with stroke outcomes. The findings could provide insights that may eventually translate into targeted interventions for stroke in humans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with a family history of stroke or those who have experienced a stroke themselves.
Not a fit: Patients who do not have a genetic predisposition to stroke or who are not affected by stroke-related conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating stroke based on genetic risk factors.
How similar studies have performed: Other research has shown success in identifying genetic factors related to stroke vulnerability, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Nowak, Thaddeus S. — University of Tennessee Health Sci Ctr
- Study coordinator: Nowak, Thaddeus S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.