Investigating genetic factors that influence resilience to tau-related brain diseases.
Official title: Systems Genetics Analysis of Resilience to Tauopathy in ADRD
Funded at University College London · NIH-11053899 · Data updated 2026-11-12
This study is looking at how our genes might help some people be more resilient to tau-related issues in Alzheimer's and similar conditions, using special mice to find clues that could lead to new treatments or ways to prevent these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University College London NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $799,700 |
| NIH project number | 1R01AG085446-01A1 |
| Project ID | NIH-11053899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or related dementias, particularly those with a family history of tauopathies.
✕Less likely to help
Patients with non-tau related forms of dementia or those without any genetic predisposition to tauopathies may not benefit from this research.
What this research studies
This research focuses on understanding how genetic differences affect the resilience to tauopathy, a key feature of Alzheimer's disease and related dementias. By using a specialized mouse model, researchers aim to identify genetic and molecular factors that contribute to resilience against these conditions. The study will explore how these factors can potentially lead to new treatments or preventive strategies for patients suffering from tau-related dementias. The findings could provide insights into the biological mechanisms that underlie the progression of these diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets that help prevent or delay the onset of Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University College London
London, United Kingdom Active
Researchers
- Principal investigator: Duff, Karen — University College London
- Study coordinator: Duff, Karen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.