Investigating genetic factors that influence protein binding in brain immune cells related to Alzheimer's disease
Official title: Genetic determinants of TF binding in pooled microglia
Funded at Icahn School of Medicine at Mount Sinai · NIH-11045825 · Data updated 2026-11-12
This study is looking at how differences in our genes might affect brain immune cells and their role in Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $464,750 |
| NIH project number | 1R21AG091272-01 |
| Project ID | NIH-11045825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with a family history or genetic predisposition.
✕Less likely to help
Patients with non-genetic forms of dementia or those without any familial or genetic risk factors for Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how genetic variations affect the binding of transcription factors in microglia, which are immune cells in the brain, and their role in Alzheimer's disease (AD). By analyzing genetic data and using advanced techniques like Chromatin immunoprecipitation followed by sequencing (ChIP-Seq), the study aims to identify specific genetic variants that may influence the function of these cells in the context of AD. This could help clarify the biological mechanisms behind AD and potentially lead to new therapeutic targets. Patients may benefit from insights gained about the genetic underpinnings of their condition.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the genetic factors involved.
How similar studies have gone: Previous research has shown promise in understanding genetic influences on neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Raj, Towfique — Icahn School of Medicine at Mount Sinai
- Study coordinator: Raj, Towfique
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.