Investigating genetic factors that influence protein binding in brain immune cells related to Alzheimer's disease
Genetic determinants of TF binding in pooled microglia
['FUNDING_R21'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11045825
This study is looking at how differences in our genes might affect brain immune cells and their role in Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11045825 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how genetic variations affect the binding of transcription factors in microglia, which are immune cells in the brain, and their role in Alzheimer's disease (AD). By analyzing genetic data and using advanced techniques like Chromatin immunoprecipitation followed by sequencing (ChIP-Seq), the study aims to identify specific genetic variants that may influence the function of these cells in the context of AD. This could help clarify the biological mechanisms behind AD and potentially lead to new therapeutic targets. Patients may benefit from insights gained about the genetic underpinnings of their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients with non-genetic forms of dementia or those without any familial or genetic risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the genetic factors involved.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAJ, TOWFIQUE — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: RAJ, TOWFIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent neurodegenerative disease, age dependent neurodegenerative disorder, age-driven neurodegenerative disorders