Investigating genetic factors that influence prostate cancer risk in diverse populations.
Official title: Germline Genetics and Risk of Prostate Cancer in Diverse Populations from the All of Us Program
Funded at Fred Hutchinson Cancer Center · NIH-10931627 · Data updated 2026-11-12
This study is looking at how genes might affect the risk of prostate cancer, especially in different groups of people like African American and Asian men, and it will also consider how things like lifestyle and environment play a role; if you join, you might get genetic testing to help understand your own risk and contribute to important research for preventing cancer in the future.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $175,207 |
| NIH project number | 5R03CA287235-02 |
| Project ID | NIH-10931627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include men of African American and Asian descent who are concerned about their prostate cancer risk.
✕Less likely to help
Patients who do not have a family history of prostate cancer or those who are not of African or Asian descent may not benefit from this research.
What this research studies
This research focuses on understanding how genetic factors contribute to the risk of prostate cancer, particularly in diverse populations, including African American and Asian individuals. By analyzing both common and rare genetic variants, the study aims to develop a more comprehensive understanding of prostate cancer risk. The research will also consider how lifestyle, environmental, and socioeconomic factors interact with genetic predispositions. Participants may undergo genetic testing to identify their risk levels and contribute to a larger database that can inform future cancer prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and personalized prevention strategies for prostate cancer in diverse populations.
How similar studies have gone: Previous research has shown success in identifying genetic risk factors for prostate cancer, but this study aims to expand knowledge specifically in underrepresented populations.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Darst, Burcu Frances — Fred Hutchinson Cancer Center
- Study coordinator: Darst, Burcu Frances
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.