Investigating genetic factors that influence inflammatory bowel disease.
Official title: Using molecular quantitative trait loci mapping approaches to determine candidate gene regulatory mechanisms of functional variants within inflammatory bowel disease GWAS loci.
Funded at Univ of North Carolina Chapel Hill · NIH-11041000 · Data updated 2026-11-12
This study is looking at how our genes might play a role in inflammatory bowel diseases like Crohn’s and ulcerative colitis, with the hope of finding better treatments by connecting genetic information to the way these diseases show up in patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $42,574 |
| NIH project number | 5F31DK137574-02 |
| Project ID | NIH-11041000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases, such as Crohn’s disease or ulcerative colitis.
✕Less likely to help
Patients without a diagnosis of inflammatory bowel disease or those with other unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research focuses on understanding the genetic mechanisms behind inflammatory bowel diseases (IBD) like Crohn’s disease and ulcerative colitis. By using advanced molecular mapping techniques, the study aims to identify how specific genetic variants affect gene regulation and contribute to the disease. The approach involves analyzing genetic data from patients to uncover the underlying causes of IBD, which could lead to more effective treatments. Patients' genetic information will be linked to their disease characteristics to better understand the role of genetics in IBD.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that address the root causes of inflammatory bowel disease rather than just managing symptoms.
How similar studies have gone: Previous research using similar genetic mapping approaches has shown promise in identifying disease mechanisms, suggesting that this study could build on established methodologies.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Nishiyama, Nina — Univ of North Carolina Chapel Hill
- Study coordinator: Nishiyama, Nina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.