Investigating genetic factors that influence Huntington's disease progression
Novel mouse genetic models to study modifiers of Huntington’s disease
This study is looking at how certain genes might change the way Huntington's disease progresses, using mice to help find out more about the symptoms and how they could lead to new treatments that might help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10655331 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic factors can modify the progression of Huntington's disease (HD), a serious neurodegenerative disorder. By using advanced mouse models, researchers will explore the role of certain genes in the onset and severity of HD symptoms, including motor and cognitive impairments. The study aims to uncover the mechanisms behind these genetic influences, which could lead to new therapeutic strategies. Patients may benefit from insights gained into how their genetic makeup could affect their disease course.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk due to family history.
Not a fit: Patients with other neurodegenerative disorders unrelated to Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Huntington's disease.
How similar studies have performed: Previous research has shown promise in understanding genetic modifiers of neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yang, Xiangdong William — University of California Los Angeles
- Study coordinator: Yang, Xiangdong William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.