Investigating genetic factors that influence heart disease and immune cell behavior
Genetic modifiers of atherosclerosis and macrophage phenotypes
This study is looking at how certain genes might influence the buildup of plaque in arteries, which can lead to heart disease, and it aims to find new ways to help treat this condition by using mice to learn more about how these genes affect immune cells involved in heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10839981 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations affect the development of atherosclerosis, a major cause of heart disease. By using advanced genetic techniques, including CRISPR, the study aims to identify genes that modify the behavior of macrophages, which are immune cells involved in lipid metabolism and inflammation. The research will involve mouse models to explore these genetic factors and their impact on heart health, potentially leading to new treatments for atherosclerosis. Patients may benefit from insights gained that could inform future therapies targeting heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with a family history of heart disease.
Not a fit: Patients with no genetic predisposition to atherosclerosis or those already receiving effective treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new drug targets and therapies for preventing or treating heart disease.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to heart disease, making this approach promising yet still innovative.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Smith, Jonathan D — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Smith, Jonathan D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.