Investigating genetic factors that influence Alzheimer's disease through microglia function
Cell autonomous and non-cell autonomous phenotypes due to genetic risk for late onset Alzheimers disease
This study is looking at how certain genetic differences might change the way brain immune cells work, which could help us understand the risk of developing Alzheimer's disease, and it’s designed for people interested in how genetics can influence brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11085281 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations, known as single nucleotide polymorphisms (SNPs), affect the function of microglia, which are immune cells in the brain. By studying these genetic factors, researchers aim to determine how they contribute to the risk of developing Alzheimer's disease. The approach involves creating microglia-like cells from patient-derived induced pluripotent stem cells (iPSCs) to explore how different genetic backgrounds influence microglial behavior and response. This could lead to insights into the mechanisms of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease, particularly those with specific SNPs related to microglial function.
Not a fit: Patients without a genetic risk for Alzheimer's disease or those who do not have the relevant SNPs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting microglial function.
How similar studies have performed: Other research has shown promising results in understanding the role of microglia in Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Poon, Wayne W — University of California-Irvine
- Study coordinator: Poon, Wayne W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.