Investigating genetic factors that increase the risk of severe Coccidioidomycosis.
Human Genetic risk factors for Disseminated Coccidioidomycosis (DCM)
This study is looking at how certain genes might make some people more likely to get severe cases of a fungal infection called Coccidioidomycosis, especially in specific racial and ethnic groups, to help us understand why some people are affected more than others.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11004688 on NIH RePORTER |
What this research studies
This research aims to identify genetic variants in individuals that may predispose them to severe disseminated Coccidioidomycosis (DCM). By analyzing a large dataset of over 600 existing genetic sequences and collecting additional samples, the study will explore how ancestry-specific genetic factors influence the severity of this fungal infection. The research will utilize advanced genomic techniques to handle and analyze vast amounts of data, focusing on specific racial and ethnic groups that are more susceptible to DCM. This comprehensive approach seeks to uncover the underlying genetic mechanisms that contribute to the disease's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from specific racial and ethnic backgrounds who are at higher risk for developing severe DCM.
Not a fit: Patients who do not belong to the identified high-risk racial or ethnic groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for preventing and treating severe cases of Coccidioidomycosis.
How similar studies have performed: Previous research has shown success in identifying genetic risk factors for other infectious diseases, suggesting that this approach could yield valuable insights for DCM as well.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Arboleda, Valerie a — University of California Los Angeles
- Study coordinator: Arboleda, Valerie a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.