Investigating genetic factors that increase the risk of blood clots.
Structural and Nucleotide Variation as Genomic Risks for Venous Thrombosis: TOPMED and INVENT Collaboration
This study is looking at how certain genetic differences might increase the risk of blood clots, like deep vein thrombosis and pulmonary embolism, and if you join, you can help researchers find out more about these genetic factors by providing a sample.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10652342 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic variations contribute to venous thromboembolism (VTE), a condition that can lead to serious complications like deep vein thrombosis and pulmonary embolism. By utilizing advanced whole-genome sequencing techniques, the study aims to identify rare genetic mutations and structural variations that may elevate the risk of developing VTE. Patients may be involved in providing genetic samples, which will help researchers uncover new insights into the genetic basis of this condition. The collaboration between multiple research groups enhances the potential for significant findings that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a family history of venous thromboembolism or those who have experienced blood clotting issues themselves.
Not a fit: Patients without a genetic predisposition to venous thromboembolism or those who have not experienced any related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and personalized treatment strategies for patients at risk of blood clots.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors associated with venous thromboembolism, indicating that this approach has potential for success.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Smith, Nicholas L — University of Washington
- Study coordinator: Smith, Nicholas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.