Investigating genetic factors that increase the risk of Barrett's esophagus and esophageal cancer
Genetic susceptibility to Barrett's esophagus: From GWAS to biology
This study is looking at how our genes might affect the risk of developing Barrett's esophagus, a condition that can lead to a serious type of cancer, to help find better ways to screen and prevent it for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11081882 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to Barrett's esophagus (BE), a condition that can lead to esophageal adenocarcinoma, a serious cancer. By analyzing genetic data from genome-wide association studies (GWAS), the team aims to identify specific genetic variants that increase the risk of developing BE. The research will utilize advanced informatics tools to prioritize these genetic variants for further biological investigation, which may help clarify the underlying mechanisms of the disease. Patients may benefit from improved screening and prevention strategies based on genetic risk factors identified through this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of gastroesophageal reflux disease (GERD) or Barrett's esophagus.
Not a fit: Patients without a history of gastroesophageal reflux or Barrett's esophagus are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better screening and prevention strategies for Barrett's esophagus and esophageal cancer, potentially saving lives.
How similar studies have performed: Previous research has successfully identified genetic risk factors for other complex diseases using similar GWAS approaches, indicating potential for success in this area as well.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Buas, Matthew Frank — Sloan-Kettering Inst Can Research
- Study coordinator: Buas, Matthew Frank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.