Investigating genetic factors that increase prostate cancer risk
Functional characterization of prostate cancer risk loci by high throughput sequencing
This study is looking at how certain tiny changes in our genes might increase the risk of prostate cancer, and it aims to help patients understand their own cancer risk better so that doctors can offer more personalized prevention and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10659186 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations, known as single nucleotide polymorphisms (SNPs), contribute to the risk of developing prostate cancer. By utilizing advanced high-throughput sequencing technologies, the study aims to identify how these SNPs affect gene regulation and cancer susceptibility. Patients may benefit from insights gained about the genetic underpinnings of their cancer risk, which could lead to more personalized prevention and treatment strategies. The research will involve analyzing the binding of transcription factors to these SNPs and their biological significance using innovative techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of prostate cancer or those who have been identified as having genetic risk factors for the disease.
Not a fit: Patients without a genetic predisposition to prostate cancer or those who do not have prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for prostate cancer patients.
How similar studies have performed: Previous research utilizing high-throughput sequencing to explore genetic risk factors in cancer has shown promising results, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Wang, Liang — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Wang, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.