Investigating genetic factors that contribute to osteoarthritis using stem cells
Genome and epigenome editing of induced pluripotent stem cells for investigating osteoarthritis risk alleles
This study is looking at how certain genetic changes might affect the way osteoarthritis develops, using special lab-grown cells to see how these changes impact cartilage health, which could help us find new ways to treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10707979 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations, known as single nucleotide polymorphisms (SNPs), influence the development of osteoarthritis (OA). By utilizing induced pluripotent stem cells (iPSCs) and advanced genome editing techniques, the researchers aim to explore the effects of these genetic factors on cartilage health and function. The study will involve creating a model system that mimics the mechanical and biochemical properties of cartilage to better understand how these SNPs affect chondrocyte behavior under stress. This innovative approach could lead to new insights into the mechanisms of OA and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of osteoarthritis or those identified as having genetic risk factors for the condition.
Not a fit: Patients who do not have genetic predispositions to osteoarthritis or those with advanced OA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients at risk of developing osteoarthritis.
How similar studies have performed: Previous research has shown promise in using genome editing techniques to study genetic factors in various conditions, suggesting potential success for this novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Guilak, Farshid — Washington University
- Study coordinator: Guilak, Farshid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.