Investigating genetic factors that contribute to atrial fibrillation
Project 1 - Genes to Function: Causal Genes and their Roles in Cardiomyocyte and Atrial Physiology
This study is looking at the genes that might make some people more likely to develop atrial fibrillation (AF), a heart condition that can cause serious problems, to help find new treatments and better understand your own risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10896383 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic causes of atrial fibrillation (AF), a condition that can lead to serious health issues like heart failure and stroke. By examining specific genetic loci associated with AF, the researchers aim to identify the causal genes and variants that increase susceptibility to this condition. The study will utilize advanced molecular techniques to explore how these genetic factors influence heart cell function and may lead to the development of targeted therapies for individuals at risk. Patients may benefit from insights into their genetic predisposition to AF and potential new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have a family history of atrial fibrillation or related cardiovascular conditions.
Not a fit: Patients without a genetic predisposition to atrial fibrillation or those who do not meet the age criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments for patients at risk of atrial fibrillation based on their genetic profiles.
How similar studies have performed: Previous studies have successfully identified genetic factors associated with atrial fibrillation, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Smith, Jonathan D — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Smith, Jonathan D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.