Investigating genetic factors that cause antibiotic resistance in certain bacteria
Official title: Genetic Factors associated with phenotypic beta-lactam resistance in extended-spectrum beta lactamase-producing Enterobacterales
Funded at University of California at Davis · NIH-11193087 · Data updated 2026-11-12
This study is looking at how certain genes in bacteria help them resist common antibiotics, so we can find better ways to treat infections and help patients get the right care faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | December 15, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $473,714 |
| NIH project number | 7R01AI175414-02 |
| Project ID | NIH-11193087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with infections caused by extended-spectrum beta-lactamase-producing Enterobacterales.
✕Less likely to help
Patients with infections caused by bacteria that do not produce extended-spectrum beta-lactamases may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic elements in bacteria contribute to their resistance against beta-lactam antibiotics, which are commonly used to treat infections. By utilizing whole genome sequencing, the study aims to improve the prediction of antibiotic resistance, allowing for more effective treatment options. The researchers will explore the role of mobile genetic elements in enhancing resistance and develop models to better predict how these bacteria respond to antibiotics. This could lead to earlier and more appropriate treatment for patients with infections caused by resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown promise in using genomic approaches to predict antibiotic resistance, suggesting that this study builds on established methodologies.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Gomez-Simmonds, Angela — University of California at Davis
- Study coordinator: Gomez-Simmonds, Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.